Articoli scientifici - 23/04/2021
Is it possible to conduct clinical trials during a pandemic? The example of a trial of hydroxychloroquine
È possibile condurre studi clinici durante una pandemia? L’esempio di uno studio sull’idrossiclorochina
Introduction
Hydroxychloroquine (HCQ), a drug normally used to treat malaria and certain autoimmune disorders, was reported to have antiviral activity in vitro against coronaviruses – and specifically SARS-CoV-2 – by researchers of the Wuhan Institute of Virology, China, at the beginning of February, early on in the COVID-19 pandemic.1 The proposed mechanism of action is that it blocks virus infection by increasing endosomal pH required for virus cell fusion and glycosylation of…